GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs703842 | 1 | rs4646536 | chr12:58157988 | XRCC6BP1 | chr12:58335445-58351051:+ | -0.24 | -4.9 | 1.31E-6 | Multiple sclerosis |
| THCA | cis | rs7552404 | 1 | rs4646961 | chr1:76217169 | ACADM | chr1:76190043-76229353:+ | 0.13 | 3.68 | 0.000262 | Blood metabolite levels;Acylcarnitine levels |
| THCA | cis | rs7552404 | 1 | rs4646961 | chr1:76217169 | MSH4 | chr1:76262630-76378923:+ | 0.25 | 4.13 | 4.3E-5 | Blood metabolite levels;Acylcarnitine levels |
| THCA | cis | rs7631605 | 1 | rs4647277 | chr3:37058509 | EPM2AIP1 | chr3:37027358-37034795:- | 0.12 | 3.46 | 0.00058 | Cerebrospinal P-tau181p levels |
| THCA | cis | rs7631605 | 1 | rs4647277 | chr3:37058509 | LRRFIP2 | chr3:37094117-37217851:- | 0.49 | 13.73 | 2.17E-36 | Cerebrospinal P-tau181p levels |
| THCA | cis | rs9790314 | 1 | rs464766 | chr3:161087592 | NMD3 | chr3:160939099-160971319:+ | -0.1 | -3.36 | 0.000846 | Morning vs. evening chronotype |
| THCA | cis | rs459482 | 1 | rs464783 | chr21:42796480 | MX1 | chr21:42792520-42831140:+ | 0.18 | 3.73 | 0.000212 | IgG glycosylation |
| THCA | cis | rs459482 | 1 | rs464783 | chr21:42796480 | TFF2 | chr21:43766469-43771208:- | 0.14 | 3.59 | 0.00036 | IgG glycosylation |
| THCA | cis | rs6827815 | 1 | rs4647934 | chr4:1016279 | DGKQ | chr4:952676-967344:- | -0.23 | -3.65 | 0.000288 | Bone mineral density |
| THCA | cis | rs6827815 | 1 | rs4647934 | chr4:1016279 | FGFRL1 | chr4:1004940-1020685:+ | -0.25 | -3.91 | 0.000107 | Bone mineral density |
| THCA | cis | rs2243480 | 1 | rs464895 | chr7:65527106 | CCT6P1 | chr7:65216092-65228661:+ | 0.4 | 6.41 | 3.43E-10 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs464895 | chr7:65527106 | CRCP | chr7:65579805-65619551:+ | -0.28 | -4.3 | 2.07E-5 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs464895 | chr7:65527106 | RABGEF1 | chr7:66093890-66276446:+ | 0.57 | 7.06 | 5.74E-12 | Diabetic kidney disease |
| THCA | cis | rs1411478 | 1 | rs4652545 | chr1:180947608 | MR1 | chr1:181003139-181024633:+ | -0.12 | -3.39 | 0.000761 | Progressive supranuclear palsy |
| THCA | cis | rs1411478 | 1 | rs4652545 | chr1:180947608 | STX6 | chr1:180913175-180992046:- | -0.2 | -4.08 | 5.22E-5 | Progressive supranuclear palsy |